منابع مشابه
Microtubules, membranes and cytokinesis
Proper division of the cell requires coordination between chromosome segregation by the mitotic spindle and cleavage of the cell by the cytokinetic apparatus. Interactions between the mitotic spindle, the contractile ring and the plasma membrane ensure that the cleavage furrow is properly placed between the segregating chromosomes and that new membrane compartments are formed to produce two dau...
متن کاملRole of microtubules in stimulating cytokinesis in animal cells.
The initiation of furrow formation is disrupted when microtubule elongation to the cell surface is inhibited either by promoting microtubule disassembly with hydrostatic pressure or by stabilizing the mitotic astral microtubules with taxol. The pressure studies confirmed Rappaport's earlier observation that stimulation of furrow formation is produced by a pair of asters and does not require chr...
متن کاملDual role for microtubules in regulating cortical contractility during cytokinesis.
Microtubules stimulate contractile-ring formation in the equatorial cortex and simultaneously suppress contractility in the polar cortex; how they accomplish these differing activities is incompletely understood. We measured the behavior of GFP-actin in mammalian cells treated with nocodazole under conditions that either completely eliminate microtubules or selectively disassemble astral microt...
متن کاملOrganization of microtubules and endoplasmic reticulum during mitosis and cytokinesis in wheat meristems.
The fine-structural changes accompanying mitosis in meristematic cells of the roots and coleoptile tissue of wheat have been studied. A band of microtubules encircling the nucleus appeared in the cytoplasm before the cells entered prophase. These microtubules were oriented at right angles to the direction of the mitotic spindle and were located at the position on the mother cell wall where the ...
متن کامل14-3-3 Coordinates Microtubules, Rac, and Myosin II to Control Cell Mechanics and Cytokinesis
BACKGROUND During cytokinesis, regulatory signals are presumed to emanate from the mitotic spindle. However, what these signals are and how they lead to the spatiotemporal changes in the cortex structure, mechanics, and regional contractility are not well understood in any system. RESULTS To investigate pathways that link the microtubule network to the cortical changes that promote cytokinesi...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2000
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(00)00746-6